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  1. Gene expression changes in the structural cells of the airways are thought to play a role in the development of asthma and airway hyperresponsiveness. This includes changes to smooth muscle contractile machine...

    Authors: Christopher D. Pascoe, Ma’en Obeidat, Bryna A. Arsenault, Yunlong Nie, Stephanie Warner, Dorota Stefanowicz, Samuel J. Wadsworth, Jeremy A. Hirota, S. Jasemine Yang, Delbert R. Dorscheid, Chris Carlsten, Tillie L. Hackett, Chun Y. Seow and Peter D. Paré
    Citation: BMC Pulmonary Medicine 2017 17:189
  2. Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. The study aimed to determine and compare the prevalence of COPD in the general population aged 45-74 years old accor...

    Authors: Edgardo Sobrino, Vilma E. Irazola, Laura Gutierrez, Chung-Shiuan Chen, Fernando Lanas, Matías Calandrelli, Jacqueline Ponzo, Nora Mores, Pamela Serón, Allison Lee, Jiang He and Adolfo L. Rubinstein
    Citation: BMC Pulmonary Medicine 2017 17:187
  3. Systemic morphine has evidence to support its use for reducing breathlessness in patients with severe chronic obstructive pulmonary disease (COPD). The effectiveness of the nebulized route, however, has not ye...

    Authors: Piotr Janowiak, Małgorzata Krajnik, Zygmunt Podolec, Tomasz Bandurski, Iwona Damps-Konstańska, Piotr Sobański, David C. Currow and Ewa Jassem
    Citation: BMC Pulmonary Medicine 2017 17:186
  4. Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three techn...

    Authors: Frederik Trinkmann, Johannes Götzmann, Daniel Saur, Michele Schroeter, Katharina Roth, Ksenija Stach, Martin Borggrefe, Joachim Saur, Ibrahim Akin and Julia D. Michels
    Citation: BMC Pulmonary Medicine 2017 17:185
  5. Transbronchial biopsy for peripheral pulmonary lesions is generally performed under X-ray fluoroscopy. Virtual bronchoscopic navigation (VBN) is a method in which virtual images of the bronchial route to the l...

    Authors: Fumihiro Asano, Takashi Ishida, Naofumi Shinagawa, Noriaki Sukoh, Masaki Anzai, Kenya Kanazawa, Akifumi Tsuzuku and Satoshi Morita
    Citation: BMC Pulmonary Medicine 2017 17:184
  6. Despite the recent increasing worldwide attention towards pulmonary hypertension (PH), its epidemiology remains poorly described in Africa. Accordingly, we performed a systematic review and meta-analysis of PH...

    Authors: Jean Joel Bigna, Jean Jacques Noubiap, Jobert Richie Nansseu and Leopold Ndemnge Aminde
    Citation: BMC Pulmonary Medicine 2017 17:183
  7. Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk. This study aim to assess differences in changes in arterial stiffness of two groups of patients, defined as having daytime sleepi...

    Authors: Maria Alexandra Mineiro, Pedro Marques da Silva, Marta Alves, Ana Luísa Papoila, Maria João Marques Gomes and João Cardoso
    Citation: BMC Pulmonary Medicine 2017 17:182
  8. Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a valuable life support in acute respiratory distress syndrome (ARDS) in adult patients. However, the success of VV-ECMO is known to be influenced by...

    Authors: Meng-Yu Wu, Yu-Sheng Chang, Chung-Chi Huang, Tzu-I Wu and Pyng-Jing Lin
    Citation: BMC Pulmonary Medicine 2017 17:181
  9. The ability of interleukins (ILs) to differentiate tuberculous pleural effusion from other types of effusion is controversial. The aim of our study was to summarize the evidence for its use of ruling out or in...

    Authors: Ni Zeng, Chun Wan, Jiangyu Qin, Yanqiu Wu, Ting Yang, Yongchun Shen, Fuqiang Wen and Lei Chen
    Citation: BMC Pulmonary Medicine 2017 17:180
  10. Equitable access to affordable medicines and diagnostic tests is an integral component of optimal clinical care of patients with asthma and chronic obstructive pulmonary disease (COPD). In Uganda, we lack cont...

    Authors: Davis Kibirige, Leaticia Kampiire, David Atuhe, Raymond Mwebaze, Winceslaus Katagira, Winters Muttamba, Rebecca Nantanda, William Worodria and Bruce Kirenga
    Citation: BMC Pulmonary Medicine 2017 17:179
  11. Guidelines recommend timely evaluation of patients with suspected lung cancer. We evaluated the impact of a Rapid Investigation Clinic (RIC) on timeliness of lung cancer diagnosis and treatment between Februar...

    Authors: Nicole Ezer, Asma Navasakulpong, Kevin Schwartzman, Linda Ofiara and Anne V. Gonzalez
    Citation: BMC Pulmonary Medicine 2017 17:178
  12. Patients with primary spontaneous pneumothorax (PSP) usually complain of sudden-onset dyspnea and pleuritic chest pain. However, asymptomatic PSP has been incidentally detected on chest X-rays. In this study, ...

    Authors: Akihisa Mitani, Yukichika Hakamata, Megumi Hosoi, Masafumi Horie, Yoko Murano, Akira Saito, Shintaro Yanagimoto, Shoji Tsuji, Kazuhiko Yamamoto and Takahide Nagase
    Citation: BMC Pulmonary Medicine 2017 17:177
  13. Inhaled corticosteroids are recommended as the first-line controller medication for childhood asthma owing to their multiple clinical benefits. However, heterogeneity in the response towards these drugs remain...

    Authors: Yi-Fan Wu, Ming-Wei Su, Bor-Luen Chiang, Yao-Hsu Yang, Ching-Hui Tsai and Yungling L. Lee
    Citation: BMC Pulmonary Medicine 2017 17:176
  14. When epidermal growth factor receptor (EGFR) gene mutation-positive non-small cell lung cancer (NSCLC) acquires resistance to the initial tyrosine kinase inhibitor (TKI) treatment, reassessing the tumor DNA by...

    Authors: Sakurako Uozu, Kazuyoshi Imaizumi, Teppei Yamaguchi, Yasuhiro Goto, Kenji Kawada, Tomoyuki Minezawa, Takuya Okamura, Ken Akao, Masamichi Hayashi, Sumito Isogai, Mitsushi Okazawa, Naozumi Hashimoto and Yoshinori Hasegawa
    Citation: BMC Pulmonary Medicine 2017 17:175
  15. Idiopathic pulmonary fibrosis (IPF) is an irreversible interstitial pulmonary disease featured by high mortality, chronic and progressive course, and poor prognosis with unclear etiology. Currently, more studi...

    Authors: Feng Yan, Zhensong Wen, Rui Wang, Wenling Luo, Yufeng Du, Wenjun Wang and Xianyang Chen
    Citation: BMC Pulmonary Medicine 2017 17:174
  16. Alectinib, a second-generation anaplastic lymphoma kinase (ALK) inhibitor, is a key drug for ALK rearranged lung adenocarcinoma. Interstitial lung disease (ILD) is an important adverse effect of alectinib, whi...

    Authors: Tatsuya Nitawaki, Yoshihiko Sakata, Kodai Kawamura and Kazuya Ichikado
    Citation: BMC Pulmonary Medicine 2017 17:173
  17. After publication of this work [1] it was noticed that the author name Rachael L. DiSantostefano was not spelt correctly as there was a space in her surname between ‘Di’ and ‘Santostefano’.

    Authors: Céline El Baou, Rachael L. DiSantostefano, Rafael Alfonso-Cristancho, Elizabeth A. Suarez, David Stempel, Mark L. Everard and Neil Barnes
    Citation: BMC Pulmonary Medicine 2017 17:172

    The original article was published in BMC Pulmonary Medicine 2017 17:31

  18. After publication of this work [1] it was noticed three author names were spelt incorrectly. Liudmila Iashyna should be Liudmyla Iashyna, Marina Polyanskaya should be Maryna Polianska and Elcan Mamamdbayov should...

    Authors: Yuriy Feshchenko, Liudmyla Iashyna, Damilya Nugmanova, Olga Gyrina, Maryna Polianska, Alexander Markov, Maryna Moibenko, Janina Makarova, Luqman Tariq, Marcelo Horacio S. Pereira, Eljan Mammadbayov, Irada Akhundova and Averyan Vasylyev
    Citation: BMC Pulmonary Medicine 2017 17:171

    The original article was published in BMC Pulmonary Medicine 2017 17:131

  19. Pneumocystis jirovecii pneumonia (PCP) is an opportunistic fungal infection that is associated with a high morbidity and mortality in immunocompromised individuals. In this study, we a...

    Authors: J. Kehrmann, B. Veckollari, D. Schmidt, O. Schildgen, V. Schildgen, N. Wagner, M. Zeschnigk, L. Klein-Hitpass, O. Witzke, J. Buer and J. Steinmann
    Citation: BMC Pulmonary Medicine 2017 17:170
  20. Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthm...

    Authors: Collin R. Brooks, Christine J. Van Dalen, Elizabeth Harding, Ian F. Hermans and Jeroen Douwes
    Citation: BMC Pulmonary Medicine 2017 17:169
  21. Although pleural fluid lactate dehydrogenase (LDH) and adenosine deaminase (ADA) levels are often used to distinguish between tuberculous pleural effusion (TPE) and parapneumonic pleural effusion (PPE), this c...

    Authors: Jinlin Wang, Jun Liu, Xiaohong Xie, Panxiao Shen, Jianxing He and Yunxiang Zeng
    Citation: BMC Pulmonary Medicine 2017 17:168
  22. N-terminal pro-brain-type natriuretic peptide (NT-proBNP) is currently used as a surrogate marker for disease severity in pulmonary hypertension (PH). However, NT-proBNP tends to have a high variability and ma...

    Authors: T. M. Berghaus, J. Kutsch, C. Faul, W. von Scheidt and M. Schwaiblmair
    Citation: BMC Pulmonary Medicine 2017 17:167
  23. Previously reported prognostic tools for patients with resected non-small cell lung cancer (NSCLC) include factors found postoperatively, but not preoperatively. However, it would be important to predict patie...

    Authors: Shogo Kumagai, Satoshi Marumo, Machiko Arita, Keiji Yamanashi, Ryota Sumitomo, Yosuke Otake, Tsuyoshi Shoji, Motonari Fukui, Toshiro Katayama, Norihito Okumura and Cheng-Long Huang
    Citation: BMC Pulmonary Medicine 2017 17:166
  24. Several studies have investigated the prevalence and risk factors of depression in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obs...

    Authors: Matthieu Hein, Jean-Pol Lanquart, Gwenolé Loas, Philippe Hubain and Paul Linkowski
    Citation: BMC Pulmonary Medicine 2017 17:165
  25. Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of ...

    Authors: Diana J. Leeming, Inger Byrjalsen, Jannie M. B. Sand, Asger R. Bihlet, Peter Lange, Ruth Thal-Singer, Bruce E. Miller, Morten A. Karsdal and Jørgen Vestbo
    Citation: BMC Pulmonary Medicine 2017 17:164
  26. Aging is a known risk factor of idiopathic pulmonary fibrosis (IPF). However, the pathogenic mechanisms underlying the effects of advanced aging remain largely unknown. Telomeric repeat-containing RNA (TERRA) ...

    Authors: Yulin Gao, Jinjin Zhang, Yuxia Liu, Songzi Zhang, Youlei Wang, Bo Liu, Huizhu Liu, Rongrong Li, Changjun Lv and Xiaodong Song
    Citation: BMC Pulmonary Medicine 2017 17:163
  27. Subcutaneous treprostinil is a prostacyclin analogue used to treat pulmonary arterial hypertension (PAH). Due to local pain it can cause a deterioration of heart related quality of life (HRQoL) or even abandon...

    Authors: Marcin Kurzyna, Katarzyna Małaczyńska-Rajpold, Andrzej Koteja, Agnieszka Pawlak, Łukasz Chrzanowski, Michał Furdal, Zbigniew Gąsior, Wojciech Jacheć, Bożena Sobkowicz, Justyna Norwa, Tatiana Mularek-Kubzdela and Adam Torbicki
    Citation: BMC Pulmonary Medicine 2017 17:162
  28. Ultrasound is a convenient tool to evaluate cardiac and diaphragm function. The ratio (E/Ea) of mitral Doppler inflow velocity to annular tissue Doppler wave velocity by transthoracic echocardiography (TTE) an...

    Authors: Ling Luo, Yidan Li, Xiukai Chen, Bing Sun, Wenxiong Li, Wei Gu, Shuo Wang, Song Zhao, Yanwei Lv, Mulei Chen, Jingen Xia, Feng Sui, Xue Mei, Huanzhong Shi and Zhaohui Tong
    Citation: BMC Pulmonary Medicine 2017 17:161
  29. Pulmonary exacerbations (PEx) are a major driver of morbidity and mortality in cystic fibrosis and reducing their frequency by extending the time between them is an important therapeutic goal. Although treatme...

    Authors: Julia C. Espel, Hannah L. Palac, Joanne F. Cullina, Alexandria P. Clarke, Susanna A. McColley, Michelle H. Prickett and Manu Jain
    Citation: BMC Pulmonary Medicine 2017 17:160
  30. Recently, it was shown that chronic tobacco smoking evokes specific cellular and molecular changes in white blood cells by an excess of G protein-coupled receptor 15 (GPR15)-expressing T cells as well as a hyp...

    Authors: Mario Bauer, Beate Fink, Hans-Jürgen Seyfarth, Hubert Wirtz and Armin Frille
    Citation: BMC Pulmonary Medicine 2017 17:159
  31. (Over-)expression of arginase may limit local availability of arginine for nitric oxide synthesis. We investigated the significance of arginase1 (ARG1) for the development of airway hyperresponsiveness (AHR) a...

    Authors: Roy H. E. Cloots, Selvakumari Sankaranarayanan, Matthew E. Poynter, Els Terwindt, Paul van Dijk, Wouter H. Lamers and S. Eleonore Köhler
    Citation: BMC Pulmonary Medicine 2017 17:158
  32. Several studies have verified body fat distribution in association with pulmonary function (PF), mainly waist circumference, but few have used measures able to distinguish abdominal fat compartments. The prese...

    Authors: Paula Duarte de Oliveira, Fernando César Wehrmeister, Bernardo Lessa Horta, Rogelio Pérez-Padilla, Giovanny Vinícius Araújo de França, Denise P. Gigante, Fernando C. Barros, Ken K. Ong, Emanuella De Lucia Rolfe and Ana Maria Baptista Menezes
    Citation: BMC Pulmonary Medicine 2017 17:157
  33. The aim of this study was to differentiate unspecific and self-limiting fever after bronchoscopy from fever due to infection by using serum procalcitonin, C-reactive protein and neutrophil count. Furthermore, ...

    Authors: Klaus Hackner, Waltraud Riegler, Sabin Handzhiev, Rosemarie Bauer, Jan Veres, Manuela Speiser, Karin Meisinger and Peter Errhalt
    Citation: BMC Pulmonary Medicine 2017 17:156
  34. To report the prevalence of pleural plaques in a lung cancer screening trial by low-dose computed tomography (LDCT) and to test the association with incidence of lung cancer and mortality.

    Authors: Mario Silva, Nicola Sverzellati, Davide Colombi, Gianluca Milanese, Carlo La Vecchia, Carlotta Galeone, Alfonso Marchianò and Ugo Pastorino
    Citation: BMC Pulmonary Medicine 2017 17:155
  35. Patients with pulmonary fibrosis (PF) have impaired quality of life, and research suggests that dyspnea and physical activity are primary drivers. As PF progresses, some patients notice the disease “shrinks th...

    Authors: Elisabeth Dowling Root, Bridget Graney, Susan Baird, Tara Churney, Kailtin Fier, Majorie Korn, Mark McCormic, David Sprunger, Tomas Vierzba, Frederick S. Wamboldt and Jeffery J. Swigris
    Citation: BMC Pulmonary Medicine 2017 17:154
  36. Despite recognition of asthma as a growing global issue and development of global guidelines, asthma treatment practices vary between countries. Several studies have reported patients’ perspectives on asthma c...

    Authors: Kenneth R. Chapman, David Hinds, Peter Piazza, Chantal Raherison, Michael Gibbs, Timm Greulich, Kenneth Gaalswyk, Jiangtao Lin, Mitsuru Adachi and Kourtney J. Davis
    Citation: BMC Pulmonary Medicine 2017 17:153
  37. Dyspnea is the hallmark symptom of pulmonary fibrosis. Supplemental oxygen (O2) is prescribed to many patients with pulmonary fibrosis in hopes of alleviating dyspnea and improving physical functioning. We used r...

    Authors: Amy L. Olson, Bridget Graney, Susan Baird, Tara Churney, Kaitlin Fier, Marjorie Korn, Mark McCormick, David Sprunger, Thomas Vierzba, Frederick S. Wamboldt and Jeffrey J. Swigris
    Citation: BMC Pulmonary Medicine 2017 17:152
  38. With the exception of areas with high prevalence of tuberculosis, medical thoracoscopy is becoming the diagnostic modality of choice for exudative pleural effusions. The aims of this study were to determine th...

    Authors: Merlin Thomas, Wanis H. Ibrahim, Tasleem Raza, Kamran Mushtaq, Adeel Arshad, Mushtaq Ahmed, Salma Taha, Saber Al Sarafandi, Hanfa Karim and Hisham A. Abdul-sattar
    Citation: BMC Pulmonary Medicine 2017 17:151
  39. Respiratory tract infection is a major cause of acute exacerbation of bronchial asthma (AEBA). Although recent findings suggest that common bacteria are causally associated with AEBA, a comprehensive epidemiol...

    Authors: Yutaka Yoshii, Kenichiro Shimizu, Miyuki Morozumi, Naoko Chiba, Kimiko Ubukata, Hironori Uruga, Shigeo Hanada, Hiroshi Wakui, Shunsuke Minagawa, Hiromichi Hara, Takanori Numata, Keisuke Saito, Jun Araya, Katsutoshi Nakayama, Kazuma Kishi and Kazuyoshi Kuwano
    Citation: BMC Pulmonary Medicine 2017 17:150
  40. The incidence of tuberculosis (TB) is high among human immunodeficiency virus (HIV) infected Ugandans. Recent evidence suggests that Chronic Pulmonary Aspergillosis and Aspergillus sensitisation might be responsi...

    Authors: Richard Kwizera, Rosalind Parkes-Ratanshi, Iain D. Page, Christine Sekaggya-Wiltshire, Joseph Musaazi, Jan Fehr, Barbara Castelnuovo, Andrew Kambugu and David W. Denning
    Citation: BMC Pulmonary Medicine 2017 17:149
  41. Sivelestat is widely used in treating acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), although the clinical efficacy of sivelestat remains controversial. This study aimed to evaluate the im...

    Authors: Shenglan Pu, Daoxin Wang, Daishun Liu, Yan Zhao, Di Qi, Jing He and Guoqi Zhou
    Citation: BMC Pulmonary Medicine 2017 17:148
  42. This study aimed to investigate clinical characteristics of Korean PAP patients and to examine the potential risk factors of PAP.

    Authors: Ji An Hwang, Joo Han Song, Jung Hoon Kim, Man Pyo Chung, Dong Soon Kim, Jin Woo Song, Young Whan Kim, Sun Mi Choi, Seung Ick Cha, Soo Taek Uh, Choon-Sik Park, Sung Hwan Jeong, Yong Bum Park, Hong Lyeol Lee, Jong Wook Shin, Eun Joo Lee…
    Citation: BMC Pulmonary Medicine 2017 17:147
  43. Combined effects of leaks, mechanical property of respiratory system and upper airway (UA) patency on patient-ventilator synchrony (PVA) and the level of clinically “tolerable” leaks are not well established i...

    Authors: Kaixian Zhu, Claudio Rabec, Jésus Gonzalez-Bermejo, Sébastien Hardy, Sami Aouf, Pierre Escourrou and Gabriel Roisman
    Citation: BMC Pulmonary Medicine 2017 17:145
  44. Asbestosis and silicosis are progressive pneumoconioses characterized by interstitial fibrosis following exposure to asbestos or silica dust. We evaluated the potential diagnostic biomarkers for these diseases.

    Authors: Changjiang Xue, Na Wu, Xue Li, Meihua Qiu, Xuqin Du and Qiao Ye
    Citation: BMC Pulmonary Medicine 2017 17:144
  45. Nasal high-flow oxygen therapy (HFOT) is a novel treatment option for patients suffering from acute or chronic respiratory failure. Aim of our study was to compare safety and efficacy of HFOT with those of con...

    Authors: Helene Vogelsinger, Michael Halank, Silke Braun, Heinrike Wilkens, Thomas Geiser, Sebastian Ott, Armin Stucki and Christian M. Kaehler
    Citation: BMC Pulmonary Medicine 2017 17:143
  46. The effects of high flow nasal cannula (HFNC) on adult patients after extubation remain controversial. We aimed to further determine the effectiveness of HFNC in comparison to noninvasive positive pressure ven...

    Authors: Yue-Nan Ni, Jian Luo, He Yu, Dan Liu, Bin-Miao Liang, Rong Yao and Zong-An Liang
    Citation: BMC Pulmonary Medicine 2017 17:142
  47. Clinical guidelines specify that diagnosis of interstitial pulmonary fibrosis (IPF) requires identification of usual interstitial pneumonia (UIP) pattern. While UIP can be identified by high resolution CT of t...

    Authors: Yoonha Choi, Jiayi Lu, Zhanzhi Hu, Daniel G. Pankratz, Huimin Jiang, Manqiu Cao, Cristina Marchisano, Jennifer Huiras, Grazyna Fedorowicz, Mei G. Wong, Jessica R. Anderson, Edward Y. Tom, Joshua Babiarz, Urooj Imtiaz, Neil M. Barth, P. Sean Walsh…
    Citation: BMC Pulmonary Medicine 2017 17:141
  48. Rehabilitation of patients with chronic obstructive pulmonary disease (COPD) is a key treatment in COPD. However, despite the existing evidence and a strong recommendation from lung associations worldwide, 50%...

    Authors: Henrik Hansen, Theresa Bieler, Nina Beyer, Nina Godtfredsen, Thomas Kallemose and Anne Frølich
    Citation: BMC Pulmonary Medicine 2017 17:140
  49. Neurally Adjusted Ventilatory Assist (NAVA) is a proportional ventilatory mode that uses the electrical activity of the diaphragm (EAdi) to offer ventilatory assistance in proportion to patient effort. NAVA ha...

    Authors: Juliana C. Ferreira, Fabia Diniz-Silva, Henrique T. Moriya, Adriano M. Alencar, Marcelo B. P. Amato and Carlos R. R. Carvalho
    Citation: BMC Pulmonary Medicine 2017 17:139

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