Skip to main content

Table 3 MLP criteria and COPD-related death: competing risk analysis with other-cause death as competing risk

From: Muscle loss phenotype in COPD is associated with adverse outcomes in the UK Biobank

Factor

Any MLP criteria

By BMI

By HGS

By FFMI

By ASMI

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

MLP

1.7 (1.5, 2.0)

< 0.001

2.2 (1.5, 3.3)

< 0.001

1.6 (1.4, 1.9)

< 0.001

2.0 (1.7, 2.4)

< 0.001

1.7 (1.4, 2.0)

< 0.001

Male vs. Female

1.4 (1.2, 1.7)

< 0.001

1.6 (1.4, 1.9)

< 0.001

1.7 (1.5, 2.0)

< 0.001

1.6 (1.4, 1.9)

< 0.001

1.2 (1.02, 1.4)

0.029

Age (years)

1.1 (1.09, 1.1)

< 0.001

1.1 (1.1, 1.1)

< 0.001

1.1 (1.10, 1.1)

< 0.001

1.1 (1.10, 1.1)

< 0.001

1.1 (1.10, 1.1)

< 0.001

BMI (1 kg/m2 increment)

1.04 (1.03, 1.06)

< 0.001

-

-

1.02 (1.01, 1.04)

0.005

1.05 (1.03, 1.06)

< 0.001

1.06 (1.04, 1.08)

< 0.001

British vs. Other Ethnicity

0.85 (0.65, 1.1)

0.240

0.84 (0.65, 1.10)

0.200

0.87 (0.66, 1.1)

0.310

0.86 (0.65, 1.1)

0.250

0.84 (0.64, 1.09)

0.190

Cancer diagnosed by doctor

0.98 (0.78, 1.2)

0.88

0.97 (0.77, 1.2)

0.81

0.98 (0.78, 1.2)

0.84

0.99 (0.79, 1.2)

0.96

0.99 (0.79, 1.2)

0.92

Current alcohol use

0.62 (0.50, 0.76)

< 0.001

0.60 (0.49, 0.74)

< 0.001

0.62 (0.51, 0.77)

< 0.001

0.60 (0.49, 0.73)

< 0.001

0.61 (0.49, 0.74)

< 0.001

Current smoker

4.6 (4.0, 5.2)

< 0.001

4.4 (3.8, 5.0)

< 0.001

4.6 (4.0, 5.2)

< 0.001

4.5 (3.9, 5.1)

< 0.001

4.5 (4.0, 5.2)

< 0.001

FEV1/FVC ratio (0.1 unit increment)

0.45 (0.42, 0.47)

< 0.001

0.45 (0.43, 0.47)

< 0.001

0.45 (0.42, 0.47)

< 0.001

0.44 (0.42, 0.47)

< 0.001

0.44 (0.42, 0.47)

< 0.001

  1. All models were fitted on each of the 5 imputed datasets and parameter estimates were combined using SAS Mianalyze. BMI was not included in the model for BMI-defined MLP criteria
  2. MLP muscle loss phenotype