Muscle loss phenotype in COPD is associated with adverse outcomes in the UK Biobank

BMC Pulmonary Medicine

Table 2 MLP criteria and all-cause death: cox regression

Factor	Any MLP criteria		MLP criteria by BMI		MLP criteria by HGS		MLP criteria by FFMI		MLP criteria by ASMI
Factor	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
MLP	1.3 (1.2, 1.4)	< 0.001	1.6 (1.3, 2.0)	< 0.001	1.4 (1.3, 1.5)	< 0.001	1.6 (1.5, 1.8)	< 0.001	1.2 (1.1, 1.3)	< 0.001
Male vs. Female	1.5 (1.4, 1.6)	< 0.001	1.6 (1.6, 1.7)	< 0.001	1.7 (1.6, 1.8)	< 0.001	1.6 (1.6, 1.7)	< 0.001	1.5 (1.4, 1.5)	< 0.001
Age (years)	1.09 (1.08,1.09)	< 0.001	1.09 (1.09, 1.10)	< 0.001	1.09 (1.08,1.10)	< 0.001	1.09 s(1.09,1.10)	< 0.001	1.09 (1.09,1.10)	< 0.001
BMI (1 kg/m² increment)	1.04 (1.03,1.04)	< 0.001	-	-	1.03 (1.02,1.03)	< 0.001	1.04 (1.03,1.05)	< 0.001	1.04 (1.03,1.05)	< 0.001
British vs. Other Ethnicity	0.92 (0.82,1.03)	0.14	0.92 (0.82, 1.02)	0.12	0.93 (0.83,1.03)	0.18	0.92 (0.82,1.03)	0.14	0.91 (0.82,1.02)	0.11
Cancer diagnosed by doctor	1.9 (1.7, 2.0)	< 0.001	1.9 (1.7, 2.0)	< 0.001	1.9 (1.7, 2.0)	< 0.001	1.9 (1.7, 2.0)	< 0.001	1.9 (1.7, 2.0)	< 0.001
Current alcohol use	0.67 (0.62,0.73)	< 0.001	0.65 (0.60, 0.71)	< 0.001	0.67 (0.62,0.73)	< 0.001	0.67 (0.61,0.73)	< 0.001	0.66 (0.61,0.72)	< 0.001
Current smoker	2.4 (2.3, 2.5)	< 0.001	2.3 (2.2, 2.5)	< 0.001	2.4 (2.3, 2.5)	< 0.001	2.4 (2.2, 2.5)	< 0.001	2.4 (2.3, 2.5)	< 0.001
FEV1/FVC ratio (0.1 unit increment)	0.73 (0.71,0.76)	< 0.001	0.74 (0.71, 0.76)	< 0.001	0.74 (0.71,0.76)	< 0.001	0.73 (0.71,0.76)	< 0.001	0.73 (0.71,0.75)	< 0.001

All models were fitted on each of the 5 imputed datasets and parameter estimates were combined using SAS Mianalyze. BMI was not included in the model for BMI-defined MLP
MLP muscle loss phenotype

ISSN: 1471-2466