| Overall, N = 279 (100%) | Donor underweight, N = 10 (3.6%) | Donor normal weight, N = 128 (46%) | Donor overweight, N = 95 (34%) | Donor obesity, N = 46 (16%) | p-value |
---|---|---|---|---|---|---|
Before surgery | ||||||
 Age, recipient, n (%) | 57 [51–62] | 56 [45–59] | 57 [50–62] | 57 [51–62] | 58 [53–63] | 0.46 |
 Male gender, recipient, n (%) | 179 (64) | 5 (50) | 83 (65) | 62 (65) | 29 (63) | 0.81 |
 Height, cm, med [IQR] | 170 [163–176] | 166 [159–175] | 171 [164–176] | 170 [163–177] | 170 [164–177] | 0.81 |
 Weight, Kg, med IQR] | 69 [58- 80] | 57 [46–78] | 71 [59–82] | 67 [57–79] | 70 [60–80] | 0.27 |
 BMI, Kg/m2, med[IQR] | 24 [21–27] | 21 [18–24] | 24 [21–27] | 23.9 [19–27] | 24 [22–28] | 0.19 |
 Diabetes mellitus, n (%) | 30 (11) | 3 (30) | 15 (12) | 10 (11) | 2 (4) | 0.12 |
 High blood pressure, n (%) | 70 (25) | 5 (50) | 29 (23) | 23 (24) | 13 (28) | 0.27 |
 Dyslipidemia, n (%) | 57 (20) | 3 (30) | 27 (21) | 19 (20) | 8 (17) | 0.79 |
 Ischc cardiopathy | 27 (10) | 1 (10) | 11 (9) | 10 (11) | 5 (11) | 0.91 |
Underlying disease | ||||||
 COPD, n (%) | 86 (31) | 1 (10) | 37 (29) | 34 (36) | 14 (30) | 0.37 |
 PF, n (%) | 130 (47) | 7 (70) | 65 (51) | 35 (37) | 23 (50) | 0.071 |
 Other, n (%) | 55 (20) | 2 (20) | 21 (16) | 22 (23) | 10 (22) | 0.59 |
 High flow oxygenotherapy before surgery, n (%) | 46 (16) | 3 (30) | 22 (17) | 15 (16) | 6 (13) | 0.59 |
 MV before surgery, n (%) | 4 (1.4) | 0 (0) | 1 (1) | 3 (3.2) | 0 (0) | 0.47 |
 ECMO support before surgery, n (%) | 21 (8) | 2 (20) | 8 (6) | 8 (8) | 3 (7) | 0.38 |
 Tobacco use, n (%) | 190 (68) | 5 (50) | 84 (66) | 70 (74) | 31 (67) | 0.34 |
 Peripheral arterial disease, n (%) | 12 (4) | 0 (0) | 7 (6) | 5 (5) | 0 (0) | 0.41 |
 Pulmonary arterial hypertension, n (%) | 134 (49) | 5 (50) | 63 (50) | 44 (47) | 22 (49) | 0.97 |
 Dilatation of the right ventricle, n (ù° | 77 (28) | 3 (30) | 32 (25) | 32 (34) | 10 (22) | 0.36 |
 Ejection fraction of the left ventricle, %, med [IQR] | 62 [58–68] | 60 [58–64] | 63 [58–69] | 61 [60–65] | 63 [55–68] | 0.15 |
 Serum creatinine, med [IQR] | 69 [56–80] | 57 [54–76] | 72 [56–84] | 65 [53–78] | 71 [59–83] | 0.083 |
 High emergency LT, n (%) | 53 (19) | 3 (30) | 23 (18) | 19 (20) | 8 (17) | 0.74 |
 Retransplantation | 7 (2.5) | 1 (10) | 4 (3) | 0 (0) | 2 (4.3) | 0.067 |
 Redux | 27 (9.9) | 2 (22) | 16 (13) | 4 (4.3) | 5 (11) | 0.066 |
During surgery | ||||||
 Bilateral LT, n (%) | 193 (69) | 6 (60) | 88 (69) | 70 (74) | 29 (63) | 0.52 |
 Duration of cold ischemia, min, first lung, med [IQR] | 277 [240–334] | 355 [285–420] | 280 [240–342] | 270 [226–330] | 278 [240–340] | 0.25 |
 Duration of cold ischemia, min, second lung, med [IQR] | 375 [308–427] | 428 [332–434] | 390 [315–448] | 360 [300–408] | 365 [300–420] | 0.20 |
 Duration of anesthesia, min, med [IQR] | 420 [360–500] | 390 [360–420] | 420 [370–500] | 420 [360–500] | 410 [353–498] | 0.66 |
Peridural anesthesia, n (%) | 185 (67) | 4 (40) | 86 (68) | 62 (67) | 33 (73) | 0.26 |
 ECMO support during surgery, n '(%) | 202 (72) | 7 (70) | 96 (75) | 62 (65) | 37 (80) | 0.23 |
 Catecholamine support during surgery, n (%) | 273 (98) | 10 (100) | 126 (98) | 92 (97) | 45 (98) | 0.89 |
 RBC transfusion during surgery, n (%) | 188 (68) | 9 (90) | 85 (67) | 66 (69) | 28 (62) | 0.40 |
 0 RBC unit, n (%) | 88 (32) | 1 (10) | 42 (33) | 29 (31) | 16 (36) |  |
 1–4 RBC units, n (%) | 137 (49) | 7 (70) | 64 (50) | 45 (47) | 21 (47) |  |
  ≥ 5 RBC units, n (%) | 52 (19) | 2 (20) | 21 (17) | 21 (22) | 8 (18) |  |
 Fresh frozen plasma transfusion, n (%) | 175 (63) | 6 (60) | 79 (62) | 61 (64) | 29 (63) | 0.98 |
 Platelet transfusion n (%) | 56 (20) | 5 (50) | 24 (19) | 16 (17) | 11 (24) | 0.094 |
 Vascular filling > 2500 mL, n (%) | 236 (85) | 10 (100) | 104 (83) | 84 (88) | 38 (83) | 0.37 |