Immature central tumor tertiary lymphoid structures are associated with better prognosis in non-small cell lung cancer

Table 1 Correlation between TLS, clinicopathological features, and CD8 staining in patients with NSCLC

Clinicopathological features	Cases	CTtotal*				IMtotal*
Clinicopathological features	Cases	Low	High	χ²	P	Low	High	χ²	P
Gender				0.000	0.988			1.833	0.176
Female	84	49	35			59	25
Male	67	39	28			40	27
Age				0.057	0.811			0.205	0.650
< 60	63	36	27			40	23
≥ 60	88	52	36			59	29
Smoking status				6.580	0.010			0.618	0.432
Non-smoker	87	57	30			57	30
Smoker	51	22	29			30	21
Differentiation				3.403	0.065			0.089	0.765
Higher differentiation	99	53	46			65	34
Middle-low differentiation	35	25	10			22	13
Histological type				0.302	0.583			0.147	0.702
Adenocarcinoma	141	83	58			93	48
Non-adenocarcinoma	10	5	5			6	4
Metastatic status				17.381	0.000			10.959	0.001
Non-metastasis	56	20	36			27	29
Metastasis	92	65	27			69	23
UICC stage				25.236	0.000			17.868	0.001
I	47	26	21			7	40
II	14	12	2			3	11
III	57	49	8			19	38
IV	32	31	1			18	14
CD8				25.795	0.000			2.986	0.084
Negative	59	49	10			44	15
Positive	84	34	50			51	33

ISSN: 1471-2466