Characteristics associated with SF-36 in alpha-1 antitrypsin deficiency-associated COPD: a cross-sectional analysis

Table 3 Multivariable associations between demographic and clinical characteristics and MCS and PCS of SF-36

	MCS^a			PCS^a
	Adjusted coefficient	95% CI	p-value	Adjusted coefficient	95% CI	p-value
Age, years
<50	REF			REF
50-65	2.59	(1.82; 3.39)	<.0001	0.20	(-0.41; 0.81)	0.5228
>65	4.74	(3.82; 5.67)	<.0001	0.43	(-0.31; 1.16)	0.2526
Sex
Male	REF			--
Female	0.79	(0.18; 1.41)	0.0117	--
mMRC^b
0	REF			REF
1	-0.45	(-1.65; 0.76)	0.4662	-3.04	(-4.0; -2.09)	<.0001
2	-1.75	(-3.00; -0.50)	0.063	-7.25	(-8.25; -6.26)	<.0001
3	-2.40	(-3.66; -1.15)	0.0002	-9.73	(-10.72; -8.74)	<.0001
4	-5.07	(-6.32; 3.82)	<.0001	-12.03	(-13.02; -11.04)	<.0001
Frequency of exacerbations in the past year
0	REF			REF
1	-0.38	(-1.32; 0.56)	0.4265	-0.46	(-1.20; 0.28)	0.2233
2 or more	-2.59	(-3.40; -1.78)	<.0001	-3.03	(-3.67; -2.38)	<.0001
Regular use of oxygen in the past year
No	REF			REF
Yes	0.30	(-0.38; 0.97)	0.3871	-2.62	(-3.15; -2.09)	<.0001
Daily productive cough for at least 3 months each year over the past 2 years
No	REF			REF
Yes	-1.21	(-1.85; -0.56)	0.0003	-1.37	(-1.88; -0.86)	<.0001

^aMCS (Mental Component Summary score) and PCS (Physical Component Summary score) have a mean of 50 (±10) in the general US population. Higher scores indicate better HRQoL
^bmodified Medical Research Council scale: 0--I only get breathless with strenuous exercise; 1 -I get short of breath when hurrying on level ground or walking up a slight hill; 2 -On level ground, I walk slower than people of the same age because of breathlessness or have to stop for breath when walking; 3 -I stop for breath after walking about 100 yards or after a few minutes on level ground; 4 -I am too breathless to leave the house, or I am breathless when dressing. Adjusted R² for the MCS model is 0.09. Adjusted R² for the PCS model is 0.30. Sex was not included in the multivariable model for PCS as not significantly associated in univariate analysis

ISSN: 1471-2466