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Table 4 Prediction of the treatment factor for mortality in patients with ILD and NSCLC assessed using the Cox proportional-hazards model

From: Clinical characteristics and outcome of lung cancer in patients with fibrosing interstitial lung disease

Variable

Univariate analysis

Multivariate analysis

HR

95% CI

P Value

HR

95% CI

P Value

ILD treatment

 Antifibrotics

0.714

0.420–1.214

0.214

   

 Corticosteroid ± IS

2.058

1.218–3.476

0.007

1.162

0.503–2.685

0.726

Acute exacerbation

2.124

1.147–3.931

0.017

1.282

0.542–3.034

0.572

Initial treatment for LC

 Surgery

0.198

0.092–0.423

< 0.001

0.235

0.106–0.522

< 0.001

 Chemotherapy

2.334

1.276–4.269

0.006

1.290

0.682–2.439

0.434

 Radiotherapy

0.781

0.412–1.480

0.449

   

 CCRT

0.916

0.222–3.776

0.904

   
  1. HR, hazard ratio; CI, confidence interval; SqCC, squamous cell carcinoma; ADC, adenocarcinoma; TLC, total lung capacity; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; DLco, diffusing capacity for carbon monoxide; IPF, idiopathic pulmonary fibrosis; ILD, interstitial lung disease; KL-6, Krebs von den Lungen-6; IS, immunosuppressant; CCRT, concurrent chemoradiation therapy
  2. Bold values denote statistical significance at the p < 0.05 level