Outcome | High adherence | Moderate adherence | High-then-poor adherence | Delayed-poor adherence | Early-poor adherence |
---|---|---|---|---|---|
Any all-cause inpatient hospital event | Â | Â | Â | Â | Â |
 Unadjusted mean | 20.40% | 22.80% | 30.00% | 29.40% | 26.80% |
 Unadjusted mean difference (95% CI) | ref | 2.4% (− 4.0%, 8.9%) | 9.6% (2.5%, 16.8%) | 9.1% (2.8%, 15.3%) | 6.4% (1.1%, 11.7%) |
  P-value |  | 0.46 | 0.008 | 0.005 | 0.02 |
 Adjusted mean difference (95% CI) | ref | 2.4% (− 4.0%, 8.7%) | 9.1% (2.2%, 16.0%) | 8.0% (1.8%, 14.2%) | 4.3% (− 0.8%, 9.4%) |
  P-value |  | 0.46 | 0.009 | 0.011 | 0.096 |
Count of all-cause inpatient hospital days | Â | Â | Â | Â | Â |
 Unadjusted mean | 1.4 | 1.4 | 3.4 | 2 | 2.5 |
 Unadjusted mean difference (95% CI) | ref | 0.0 (− 0.7, 0.7) | 2.0 (0.7, 3.3) | 0.7 (0.0, 1.3) | 1.1 (0.4, 1.9) |
  P-value |  | 0.94 | 0.003 | 0.07 | 0.003 |
 Adjusted mean difference (95% CI) | ref | 0.0 (− 0.7, 0.8) | 1.8 (0.6, 2.9) | 0.5 (− 0.1, 1.2) | 0.8 (0.1, 1.5) |
  P-value |  | 0.9 | 0.003 | 0.11 | 0.02 |
Total all-cause medical spending | Â | Â | Â | Â | Â |
 Unadjusted mean | $12,648 | $13,581 | $17,550 | $15,375 | $18,110 |
 Unadjusted mean difference (95% CI) | ref | $933 (−$1,880, $3,746) | $4,902 ($768, $9,036) | $2,727 ($323, $5,131) | $5,462 ($2,521, $8,404) |
  P-value |  | 0.52 | 0.02 | 0.03 | < 0.001 |
 Adjusted mean difference (95% CI) | ref | $523 (−$1,488, $2,534) | $4,876 ($1,470, $8,282) | $3,639 ($1,322, $5,955) | $3,907 ($1,658, $6,156) |
  P-value |  | 0.61 | 0.005 | 0.002 | < 0.001 |
Any IPF-related inpatient hospital event | Â | Â | Â | Â | Â |
 Unadjusted mean | 10.80% | 11.40% | 19.50% | 14.10% | 12.20% |
 Unadjusted mean difference (95% CI) | ref | 0.6% (− 4.3%, 5.5%) | 8.7% (2.7%, 14.8%) | 3.4% (− 1.4%, 8.2%) | 1.4% (− 2.6%, 5.4%) |
  P-value |  | 0.8 | 0.005 | 0.17 | 0.49 |
 Adjusted mean difference (95% CI) | ref | 0.8% (− 4.0%, 5.7%) | 8.4% (2.5%, 14.2%) | 3.0% (− 1.9%, 7.9%) | 0.4% (− 3.4%, 4.2%) |
  P-value |  | 0.74 | 0.005 | 0.23 | 0.84 |
Count of IPF-related inpatient hospital days | Â | Â | Â | Â | Â |
 Unadjusted mean | 0.7 | 0.6 | 1.9 | 0.7 | 0.9 |
 Unadjusted mean difference (95% CI) | ref | −0.2 (− 0.5, 0.2) | 1.2 (0.3, 2.1) | 0.0 (− 0.4, 0.4) | 0.2 (− 0.2, 0.7) |
  P-value |  | 0.37 | 0.01 | 0.98 | 0.34 |
 Adjusted mean difference (95% CI) | ref | −0.2 (− 0.5, 0.1) | 1.2 (0.4, 2.1) | 0.1 (− 0.3, 0.5) | 0.2 (− 0.2, 0.6) |
  P-value |  | 0.29 | 0.005 | 0.64 | 0.34 |
Total IPF-related medical spending | Â | Â | Â | Â | Â |
 Unadjusted mean | $3,240 | $2,936 | $6,012 | $3,697 | $3,861 |
 Unadjusted mean difference (95% CI) | ref | −$304 (−$1,075, $467) | $2,772 ($422, $5,122) | $457 (−$459, $1,372) | $621 (−$772, $2,014) |
  P-value |  | 0.44 | 0.02 | 0.33 | 0.38 |
 Adjusted mean difference (95% CI) | ref | −$299 (−$1,080, $482) | $2,205 ($455, $3,955) | $743 (−$244, $1,729) | $66 (−$815, $948) |
  P-value |  | 0.45 | 0.014 | 0.14 | 0.88 |
Sample size, n (%) | 781 (43.4) | 202 (11.2) | 190 (10.6) | 255 (14.2) | 370 (20.6) |