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Table 3 Suggested top drug compounds for COVID-19 and OSA

From: Identification of biomarkers and pathways for the SARS-CoV-2 infections in obstructive sleep apnea patients based on machine learning and proteomic analysis

Term

P-value

Adjusted P-value

Genes

acetaminophen CTD 00005295

5.67E-06

0.002117207

RB1;PCNA;CAV1;CD109;FTH1;UBE2T;

NF1;SMARCAD1;PLS3;PLOD2;NCAPD2

5-Fluorouracil CTD 00005987

6.57E-06

0.002117207

RB1;PCNA;CAV1;PLK2;UBE2T;PLOD2;HIF1A

genistein CTD 00007324

7.70E-06

0.002117207

RB1;PCNA;CAV1;PLK2;UBE2T;NCAPD2;HIF1A

estradiol CTD 00005920

9.25E-06

0.002117207

RB1;PCNA;CAV1;PLK2;CD109;FTH1;

UBE2T;NF1;PLS3;PLOD2;NCAPD2

topotecan CTD 00007293

2.16E-05

0.003806737

PCNA;FTH1;PLOD2;HIF1A

POTASSIUM NITRATE CTD 00001112

2.49E-05

0.003806737

PCNA;FTH1

simvastatin CTD 00007319

4.64E-05

0.004501554

RB1;PCNA;CAV1;HIF1A

7646–79-9 CTD 00000928

4.78E-05

0.004501554

PCNA;CAV1;PLK2;FTH1;UBE2T;PLS3;

PLOD2;NCAPD2;HIF1A

Pinosylvin CTD 00002139

4.91E-05

0.004501554

RB1;PCNA;FTH1

2,4-dichlorophenoxyacetic acid CTD 00007028

5.43E-05

0.004501554

PCNA;FTH1