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Table 2 Clinical characteristics according to the presence of each positive STM in NCFB patients

From: The clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive serum tumor markers: a retrospective study

Variables

CYFRA21-1 (+)

n = 125

CA199 (+)

n = 100

SCC (+)

n = 80

NSE (+)

n = 70

CA125 (+)

n = 66

CA724 (+)

n = 40

CEA (+)

n = 8

Demographics

       

Age, y

63 (56,70)*

62 (55,69)*

63 (55,67)*

62 (54,68)*

64 (56,71)*

62 (51,67)

55 (44,62)

Sex, F, n (%)

78 (62.4)

72 (72.0)

38 (47.5)*

45 (64.3)

37 (56.1)*

24 (60.0)

5 (62.5)

BMI, kg/cm2

22.1 (19.1,25.3)

20.4 (18.2,23.7)*

20.0 (18.0,23.8)*

22.5 (19.6,24.2)

19.6 (17.3,22.9)*

20.4 (18.0,23.5)*

22.9 (21.2,27.2)

Clinical symptoms, n (%)

       

 Fever

34 (27.2)

39 (34.8)*

31 (38.8) *

26 (37.1)*

25 (37.9) *

18 (45.0)*

1 (0.9)

 mMR C > 2

64 (51.2)*

54 (54.0)*

49 (61.3)*

31 (44.3)

40 (60.6)*

23 (57.5)*

7 (87.5)*

Disease duration, y

2 (0,10)

4 (0,22)*

2 (0,14)

5 (0,13)

5 (0,20)*

4 (0,17)

0 (0,25)

Laboratory

       

 WBC (×109 mL − 1)

6.44 (5.08,8.15)

6.71 (5.55,8.40)

7.04 (5.52,9.19)

6.38 (5.27,8.75)

7.28 (5.89,9.68)*

7.48 (6.46,10.46)*

7.38(6.07,11.5)

 NEU (×109 mL − 1)

3.93 (2.76,5.33)

4.21 (3.10,5.69)

4.36 (2.99,6.46)*

3.92 (2.93,6.27)

5.12 (3.72,7.58)*

4.98 (3.91,7.29)*

4.35(3.28,10.00)

 CRP, mg/ L

6.8 (2.9,19.6)

9.7 (4.1,38.9)*

15.2 (5.7,74.7)*

10.0 (3.0,31.7) *

25.6 (6.8,79.0)*

25.9 (6.2,83.6)*

2.7(2.4,12.5)

 ESR, mm/h

14 (5,34)

24 (12,41)*

24 (10,48)*

19 (9,37)*

34 (20,54)*

34 (11,49)*

6 (3,26)

 Fbg, g/L

3.41 (2.64,4.02)*

3.71 (3.05,4.61)*

3.79 (3.20,4.82)*

3.45 (2.91,4.61)*

4.52 (3.57,5.48)*

4.09 (3.22,5.40)*

2.81 (2.17,3.68)

 D-Dimer, ng/mL

386 (248,720)

416 (282,793)

518 (295,1047) *

508 (298,959)*

899 (499,1706)*

735 (324,1552) *

222 (190,404)

 ALB, g/L

38.9 (36.3,41.0)

38.0 (35.8,39.9)

36.6(33.7,39.6)*

38.2 (35.9,39.8)

36.2 (32.8,38.6)*

37.4 (32.8,41.4)*

40.2 (38.0,43.11)

 PAB, ng/dL

19 (14,24)

15 (11,22)*

14 (9,20)*

18 (13,23)

10 (7,16)*

15 (7,20)*

29 (23,30)*

 GLB, g/L

28.0 (25.5,32.4)

29.5 (26.2,33.1)*

29.6 (26.7,35.1)*

28.6 (26.5,33.4)

32.1 (27.5,38.3)*

32.3 (26.5,38.3)*

29.4 (26.4,31.1)

 A/G

1.4 (1.2,1.5)

1.3 (1.1,1.5)*

1.3 (1.0,1.5)*

1.4 (1.1,1.5)*

1.2 (0.9,1.4)*

1.2 (0.9,1.5)*

1.4 (1.3,1.5)

Microbiology, n (%)

       

Organism identified

41 (32.8)

45 (45.0)*

30 (37.5)

17 (24.3)

27 (40.9)*

16 (40.0)

3 (37.5)

P. aeruginosa

21 (16.8)

28 (28.0)*

22 (27.5)*

12 (17.1)

17 (25.8)*

7 (17.5)

1 (12.5)

 Others

20 (16)

17 (17)

8 (10)

5 (7.1)

10 (15.2)

9 (22.5)

2 (25.0)

Radiological

       

The number of affected lobes

4 (3,5)*

4 (4,5)*

4 (4,6)*

4 (3,5)*

5 (4,5)*

4 (3,5)*

4 (2,4)

Unilateral/Bilateral, n.

21/104*

14/86*

7/73*

14/56*

3/63*

6/34*

1/7

Involvement of lobes, n (%)

       

 Left upper lobe

49 (39.2)

46 (46.0)*

43 (53.8)*

26 (37.1)

37 (56.1)*

16 (40.0)

1 (12.5)

 Lingula

96 (76.8)*

85 (85.0)*

70 (87.5)*

45 (64.3)

64 (97.0)*

31 (77.5)*

5 (62.5)

 Left lower lobe

95 (76.0)

89 (89.0)*

67 (83.8)*

54 (77.1)

61 (92.4)*

29 (72.5)

7 (87.5)

 Right upper lobe

71 (56.8)

65 (65.0)*

52 (65.0)*

37 (52.9)

51 (77.3)*

25 (62.5)

2 (25.0)

 Right middle lobe

95 (76.0)*

77 (77.0)*

63 (78.8)*

44 (62.9)

60 (90.9)*

29 (72.5)*

6 (75.0)

 Right lower lobe

93 (74.4)*

77 (77.0)*

70 (87.5)*

49(70.0)

58 (87.9)*

33 (82.5)*

7 (87.5)

Length of hospital, d

11 (9,13)

11 (8,14)

11 (8,14)

11 (8,14)

13 (10,16)*

14 (9,18)*

12 (7,16)

  1. Definition of abbreviations: BMI body mass index, COPD chronic obstructive pulmonary disease, mMRC modified British medical research council, WBC white blood cell, NEU neutrophil, CRP C-reactive protein, PCT procalcitonin, ESR erythrocyte sedimentation rate, Fbg fibrinogen, ALB albumin, PAB prealbumin, A/G Albumin/Globulin Ratio, PaO2 partial pressure of oxygen, PaCO2, partial pressure of carbon dioxide; Data are presented as median (IQR) for continuous variables and number (percentage) for categorized variables. * p-value< 0.05