Serum levels of interleukins and S100A8/A9 correlate with clinical severity in patients with dermatomyositis-associated interstitial lung disease

Table 1 Clinical characteristic of the DM-ILD patients and healthy controls

Variables	Healthy Controls (n = 30)	DM without ILD (n = 14)	DM-ILD (n = 40)
Age at onset (years), mean ± SD	45.4 ± 10.3	52.6 ± 19.9	50.1 ± 13.3
Gender (female/male)	19/11	11/3	27/13
Subtype of DM (DM/CADM)		12/2	18/22
Subtype of ILD
A/SIP in all			17
CIP in all			13
Pulmonary function tests
HRCT score			144.5 ± 37.21
%FVC (%)		84.2 ± 14.6	67.2 ± 19.6
%DLCO (%)		52.0 ± 26.3	37.4 ± 18.5
Laboratory findings
CRP (mg/dL)	4.1 ± 3.0	5.9 ± 5.4	13.5 ± 15.5
ESR (mm/h)	7.7 ± 6.0	20.6 ± 14.4	24.9 ± 21.5
Ferritin (ng/mL)	172.6 ± 147.5	238.0 ± 244.7	758.7 ± 1036.7
CK (U/l)	75.3 ± 29.2	100.0 ± 49.3	152.3 ± 204.7

^aA/SIP Acute/subacute interstitial pneumonia, CADM clinically amyopathic dermatomyositis, CIP Chronic interstitial pneumonia, CK creatine kinase, CRP C-reactive protein, DLCO% % diffusing capacity of the lungs for carbon monoxide, DM dermatomyositis, ESR erythrocyte sedimentation rate, FVC% % forced vital capacity, HRCT high-resolution computed tomography, ILD interstitial lung disease

ISSN: 1471-2466