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Fig. 2 | BMC Pulmonary Medicine

Fig. 2

From: Fatal interstitial lung disease associated with Crizotinib pathologically confirmed by percutaneous lung biopsy in a patient with ROS1-rearranged advanced non-small-cell lung cancer: a case report

Fig. 2

a-c HE staining (× 200), (× 400), (× 200), liquid-based cell smear and a cell wax block revealed that tumour cells with gigantic nucleoli were distributed in clusters and presented with a round-edge, strongly encapsulated, obviously three-dimensional structure. Fig. 2d-l HE staining showed histological characteristics of acute interstitial pneumonia. Fig. 2d (× 200) Diffuse alveolar oedema, thickening of the septa. Fig. 2e (× 400) Macrophages or foamy macrophages prominently present in differently sized alveolar spaces. Fig. 2f (× 200) Mild infiltration of inflammatory cells in the interstitium. Fig. 2g (× 400) Rare and atypical hyaline membrane formations in alveolar spaces. Fig. 2h (× 400) Multiple hyaline thrombi (microthrombi) in pulmonary arterioles of partial areas. Fig. 2i (× 400) Atypical hyperplasia of type II alveolar epithelial cells in localized areas

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