Skip to main content

Table 4 Association between vitamin D deficiency and host genotype, stratified by vitamin D status

From: Vitamin D deficiency associates with susceptibility to tuberculosis in Pakistan, but polymorphisms in VDR, DBP and CYP2R1 do not

SNP, gene

Genotype

Serum 25(OH) D ≤20 nmol/l

Serum 25(OH) D >20 nmol/l

  
  

TB cases

Controls

OR(95 % CI)

P

TB cases

Control

OR(95 % CI)

P

Adjusted ratio of odds ratiosa

P interaction

rs7312236, VDR

AA

30/102(29 %)

12/24(50 %)

Ref

-

54/128(42 %)

30/76(40 %)

Ref

-

Ref

-

AG/GG

72/102(71 %)

12/24(50 %)

2.40(0.96-5.94)

0.054

74/128(58 %)

46/76(60 %)

0.89(0.50-1.59)

0.70

1.65(0.59-4.58)

0.33

rs154410, VDR

CC

16/105(15 %)

8/25(32 %)

Ref

-

37/130(29 %)

21/81(26 %)

Ref

 

Ref

-

CT/TT

89/105(85 %)

17/25(68 %)

2.61(0.96-7.07)

0.052

93/130(71 %)

60/81(74 %)

0.88(0.47-1.64)

0.68

2.16(0.69-6.75)

0.18

rs228570, VDR

GG

60/105(57 %)

13/25(52 %)

Ref

-

77/130(59 %)

55/82(67 %)

Ref

 

Ref

-

GA/AA

45/105(43 %)

12/25(48 %)

0.81(0.33-1.94)

0.64

53/130(41 %)

27/82(33 %)

1.40(0.78-2.5)

0.25

0.48(0.17-1.29)

0.14

rs10500804, CYP2R1

GG

27/102(26 %)

6/23(26 %)

Ref

-

32/129(25 %)

16/80(20 %)

Ref

 

Ref

-

GT/TT

75/102(74 %)

17/23(74 %)

0.98(0.35-2.74)

0.97

97/129(75 %)

64/80(80 %)

0.75(0.38-1.49)

0.42

1.51(0.47-4.8)

0.48

rs2060793, CYP2R1

GG

48/104(46 %)

11/22(50 %)

Ref

-

64/124(52 %)

40/79(51 %)

Ref

 

Ref

-

AG/AA

56/104(54 %)

11/22(50 %)

1.16(0.46-2.92)

0.74

60/124(48 %)

39/79(49 %)

0.96(0.54-1.69)

0.89

1.02(0.37-2.78)

0.96

rs10766197, CYP2R1

AA

23/104(22 %)

4/23(17 %)

Ref

-

29/128(23 %)

15/81(19 %)

Ref

 

Ref

-

AG/GG

81/104(78 %)

19/23(83 %)

0.74(0.22-2.39)

0.60

99/128(77 %)

66/81(81 %)

0.77(0.38-1.55)

0.47

1.25(0.35-4.45)

0.72

rs7041, DBP

AA

27/104(52 %)

4/23(43.5 %)

Ref

-

26/133(20 %)

19/74(47 %)

Ref

 

Ref

-

AC/CC

77/10(35 %)

19/23(43.5 %)

0.60(0.18-1.9)

0.39

107/133(80 %)

55/74(45 %)

1.42(0.72-2.79)

0.30

1.15(0.34-3.88)

0.81

rs4588, DBP

GG

55/105(52 %)

10/24(42 %)

Ref

-

68/135(50 %)

38/76(50 %)

Ref

-

Ref

-

GT/TT

50/105(48 %)

14/24(58 %)

0.64(0.26-1.59)

0.34

67/135(50 %)

38/76(50 %)

0.98(0.56-1.72)

0.95

0.93(0.35-2.48)

0.89

  1. aAdjusted for monthly income and vitamin D status, SNP single nucleotide polymorphism, Ref Referent category; VDR, Vitamin D receptor; CYP2R1, Vitamin D 25-hydroxylase; DBP, Vitamin D binding protein. The total number of samples is less than 260 and 112 in cases and controls respectively due to failed genotyping for some samples
Back to article page

BMC Pulmonary Medicine

ISSN: 1471-2466

Contact us