Table 2 Ventilator course between days 0 and 7 according to Berlin and LIS categories of ARDS

Ventilator course D0-7

Mechanical ventilation D0

47 (89)

9 (100)

32 (100)

7 (100)

0.12

duration, days

22 (30)

23 (27)

22 (25)

16 (26)

0.85

P_aO₂/F_IO₂ ratio D0

180 (76)

226 (60)

155 (49)

89 (32)

<0.001

P_aO₂/F_IO₂ ratio D1

191 (66)

208 (64)

156 (34)

91 (0)

<0.001

P_aO₂/F_IO₂ ratio D2

194 (105)

252 (41)

168 (35)

68 (0)

<0.001

P_aO2/F_IO₂ ratio D7

189 (110)

239 (23)

161 (48)

73 (21)

<0.001

PEEP D0, cmH₂0

8 (7)

8 (4)

10 (4)

10 (2)

0.10

PEEP D1, cmH₂0

8 (7)

8 (6)

10 (4)

13 (0)

0.13

PEEP D2, cmH₂0

8 (7)

10 (6)

10 (4)

8 (0)

0.40

PEEP D7, cmH₂0

6 (6)

11 (7)

9 (4)

13 (8)

0.001

Compliance D0, mL/cmH₂0

32 (23)

39 (13)

38 (23)

36 (27)

0.88

Compliance D1, mL/cmH₂0

39 (18)

35 (24)

35 (18)

21 (0)

0.24

Compliance D2, mL/cmH₂0

35 (20)

40 (30)

35 (20)

33 (0)

0.78

Compliance D7, mL/cmH₂0

47 (34)

31 (12)

37 (24)

19 (9)

0.11

Tidal volume D0, mL

500 (217)

500 (116)

520 (206)

530 (256)

0.92

Tidal volume D1, mL

520 (120)

500 (140)

500 (210)

530 (150)

0.68

Tidal volume D2, mL

520 (123)

500 (147)

505 (250)

550 (300)

0.78

Tidal volume D7, mL

530 (192)

463 (216)

500 (150)

450 (250)

0.17

Chest radiograph D0, quadrants

1 (1)

2 (0)

2 (1)

2 (1)

<0.001

Chest radiograph D1, quadrants

1 (1)

2 (0)

2 (1)

2

<0.001

Chest radiograph D2, quadrants

1 (1)

2 (1)

2 (1)

3

<0.001

Chest radiograph D7, quadrants

0 (1)

2 (0)

2 (2)

3 (1)

<0.001

LIS category

LIS <1

LIS 1.0-2.5

LIS >2.5

N =14

N = 69

N =18

P-value

Ventilator course D0-7

Mechanical ventilation D0

10 (71)

67 (97)

18 (100)

0.001

duration, days

11 (20)

22 (27)

28 (21)

0.07

P_aO₂/F_IO₂ ratio D0

214 (130)

174 (68)

112 (70)

<0.001

P_aO₂/F_IO₂ ratio D1

238 (157)

184 (60)

149 (40)

<0.001

P_aO₂/F_IO₂ ratio D2

284 (111)

181 (72)

156 (48)

<0.001

P_aO₂/F_IO₂ ratio D7

269 (162)

177 (79)

102 (78)

<0.001

PEEP D0, cmH₂0

5 (2)

9 (6)

14 (3)

<0.001

PEEP D1, cmH₂0

5 (1)

9 (4)

13 (4)

<0.001

PEEP D2, cmH₂0

5 (1)

9 (5)

12 (6)

<0.001

PEEP D7, cmH₂0

4 (3)

8 (6)

14 (5)

<0.001

Compliance D0, mL/cmH₂0

44 (57)

39 (20)

27 (18)

<0.001

Compliance D1, mL/cmH₂0

51 (25)

37 (18)

28 (21)

<0.001

Compliance D2, mL/cmH₂0

61 (105)

35 (19)

31 (21)

0.01

Compliance D7, mL/cmH₂0

65 (75)

37 (24)

20 (11)

0.007

Tidal volume D0, mL

409 (268)

500 (176)

550 (154)

0.39

Tidal volume D1, mL

523 (177)

500 (166)

523 (95)

0.92

Tidal volume D2, mL

490 (138)

525 (133)

535 (194)

0.43

Tidal volume D7, mL

450 (150)

500 (213)

500 (138)

0.71

Chest radiograph D0, no quadrants

0 (1)

2 (1)

2 (3)

<0.001

Chest radiograph D1, no quadrants

1 (1)

1 (1)

2 (2)

<0.001

Chest radiograph D2, no quadrants

0 (1)

2 (1)

2 (3)

<0.001

Chest radiograph D7, no quadrants

1 (0)

2 (1)

2 (1)

0.005