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Table 3 Univariate and multivariate analysis of prognosis for patients with NSCLC

From: Immature central tumor tertiary lymphoid structures are associated with better prognosis in non-small cell lung cancer

Clinicopathological features

Univariate analysis

Multivariate analysis

Hazard ratio (HR) (95% CI)

P

HR (95% CI)

P

Differentiation

2.056 (1.318–3.209)

0.002

1.516 (0.963–2.387)

0.073

UICC stage

16.236 (9.592–27.281)

< 0.001

7.416 (4.218–13.038)

< 0.001

Metastasis

12.001 (6.689–21.532)

< 0.001

8.819 (4.540–17.134)

< 0.001

Agg (CT)

0.272 (0.161–0.460)

< 0.001

0.401 (0.217–0.739)

0.003

FOL-I (CT)

0.212 (0.093–0.485)

< 0.001

0.267 (0.095–0.749)

0.012

FOL-II (CT)

0.226 (0.056–0.917)

0.007

0.267 (0.063–1.125)

0.072

Total (CT)*

0.319 (0.209–0.487)

< 0.001

0.560 (0.335–0.936)

0.027

Agg (IM)

0.335 (0.226–0.497)

< 0.001

0.762 (0.469–1.236)

0.271

FOL-I (IM)

0.624 (0.419–0.931)

0.021

0.774 (0.494–1.214)

0.265

FOL-II (IM)

0.432 (0.201–0.932)

0.032

0.699 (0.314–1.553)

0.379

Total (IM)*

0.356 (0.226–0.561)

< 0.001

0.640 (0.383–1.068)

0.088

Overall (CT + IM)*

0.273 (0.165–0.451)

< 0.001

0.435 (0.246–0.769)

0.004

  1. *Total (CT):the TLS percentage of all maturity in the central tumor area
  2. *Total (IM): the TLS percentage of all maturity in the invasive margin area