Immature central tumor tertiary lymphoid structures are associated with better prognosis in non-small cell lung cancer

Table 2 Correlation between different TLS maturity and clinicopathological features in patients with NSCLC

Clinicopathological features	Cases		TLS(CT)*									TLS(IM)*									TLS*
			Agg			FOL-I			FOL-II			Agg			FOL-I			FOL-II			(Overall)
		Low	High	P	Low	High	P	Low	High	P	Low	High	P	Low	High	P	Low	High	P	Low	High	P
Gender				0.45			0.133			0.742			0.952			0.497			0.958			0.834
Female	84	51	33	0.45	59	25	0.133	70	14	0.742	55	29	0.952	51	33	0.497	75	9	0.958	60	24	0.834
Male	67	44	23		50	17		57	10		40	27		37	30		60	7		46	21
Ages				0.983			0.308			0.221			0.42			0.811			0.862			0.945
<60	63	39	24		48	15		52	11		40	23		36	27		56	7		44	19
≥ 60	88	56	32		61	27		75	13		55	33		52	36		79	9		62	26
Smoking status				0.272			0.037			0.974			0.923			0.053			0.05			0.006
Non-smoking	87	60	27		69	18		75	12		53	34		54	33		81	6		67	20
Smoking	51	25	26		29	22		39	12		30	21		23	28		42	9		27	24
Differentiation				0.04			0.119			0.879			0.642			0.658			0.232			0.466
Higher differentiation	99	60	39		68	31		81	18		62	37		58	41		86	13		68	31
Middle -low differentiation	35	24	11		28	7		31	4		21	14		22	13		33	2		26	9
Histological type				0.539			0.672			0.439			0.543			0.583			0.949			0.974
Adenocarcinoma	141	88	53		101	40		117	24		89	52		83	58		126	15		99	42
Non-adenocarcinoma	10	7	3		8	2		10	0		6	4		5	5		9	1		7	3
Metastasis status				0			0.001			0.139			0			0.154			0.031			0
Non-metastasis	56	24	32		30	26		39	17		25	31		28	28		46	10		28	28
Metastasis	92	68	24		76	16		85	7		67	25		57	35		86	6		75	17
UICC stage				0			0.008			0.13			0			0.028			0.119			0
I	47	18	29		23	24		30	17		18	29		22	25		38	9		20	27
II	14	8	6		8	6		13	1		10	4		10	4		13	1		11	3
III	57	37	20		45	12		53	4		37	20		31	26		52	5		43	14
IV	32	31	1		32	0		30	2		29	3		24	9		31	1		31	1
CD8				0.001			0.025			0.089			0.175			0.088			0.31			0.013
Negative	59	45	14		51	8		53	6		42	17		40	19		55	4		48	11
Positive	84	45	39		54	30		67	17		49	35		45	39		74	10		53	31

^*TLS(CT):theTLS percentage of different maturity in the central tumor area
^*TLS(IM): the TLS percentage of different maturity in the invasive margin area
^*TLS(Overall): the TLS percentage of all maturity in the both central tumor and invasive margin area

ISSN: 1471-2466